Delayed Infusion Reactions to Enzyme Replacement Therapies.

ABSTRACT:

Background

There are currently ten intravenous enzyme replacement therapy (ERT) products available for the treatment of eight different lysosomal diseases (LD) in the USA. Additional ERT products are in clinical trials. The most common ERT adverse events are infusion reactions (IR). While IR are often defined as hypersensitivity or anaphylactoid reactions occurring concurrently with (i.e., during) infusion administration (CIR), there exists the potential for delayed infusion reactions (DIR), which present after completion of infusion administration.

Hypothesis

Concurrent infusion reactions (CIR) are not the only infusion reactions associated with enzyme therapy.

Methods

This study evaluated the occurrence of infusion reactions in 46 patients with LD who had received E

SUBMITTER: Karimian Z 

PROVIDER: S-EPMC5509557 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature