Genetic Approaches to Understanding Psychiatric Disease.

ABSTRACT: Human genetic studies have been the driving force in bringing to light the underlying biology of psychiatric conditions. As these studies fill in the gaps in our knowledge of the mechanisms at play, we will be better equipped to design therapies in rational and targeted ways, or repurpose existing therapies in previously unanticipated ways. This review is intended for those unfamiliar with psychiatric genetics as a field and provides a primer on different modes of genetic variation, the technologies currently used to probe them, and concepts that provide context for interpreting the gene-phenotype relationship. Like other subfields in human genetics, psychiatric genetics is moving from microarray technology to sequencing-based approaches as barriers of cost and expertise are removed, and t

SUBMITTER: Michaelson JJ 

PROVIDER: S-EPMC5509640 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature