Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery.

ABSTRACT:

Aim

Tranexamic acid (TXA) continues to be one of the antifibrinolytics of choice during paediatric cardiac surgery. However, in infants less than 1 year of age, the optimal dosing based on pharmacokinetic (PK) considerations is still under discussion.

Methods

Forty-three children less than 1 year of age were enrolled, of whom 37 required the use of cardiopulmonary bypass (CPB) and six were operated on without CPB. Administration of 50 mg kg^-1 TXA intravenously at the induction of anaesthesia was followed by 50 mg kg^-1 into the CPB prime in the CPB group. Plasma concentrations of TXA were analysed by gas chromatography-mass spectrometry. PK data were investigated using nonlinear mixed-effect models.

Results

A two-compartment model was fitted, with

SUBMITTER: Gertler R 

PROVIDER: S-EPMC5510067 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature