Perfluorocarbon/Gold Loading for Noninvasive in Vivo Assessment of Bone Fillers Using ¹⁹F Magnetic Resonance Imaging and Computed Tomography.

ABSTRACT: Calcium phosphate cement (CPC) is used in bone repair because of its biocompatibility. However, high similarity between CPC and the natural osseous phase results in poor image contrast in most of the available in vivo imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI). For accurate identification and localization during and after implantation in vivo, a composition with enhanced image contrast is needed. In this study, we labeled CPC with perfluoro-15-crown-5-ether-loaded (PFCE) poly(latic-co-glycolic acid) nanoparticles (hydrodynamic radius 100 nm) and gold nanoparticles (diameter 40 nm), as ¹⁹F MRI and CT contrast agents, respectively. The resulting CPC/PFCE/gold composite is implanted in a rat model for in vivo longitudinal imaging. Our f

SUBMITTER: Mastrogiacomo S 

PROVIDER: S-EPMC5510087 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature