Halogen Bonding: A Powerful Tool for Modulation of Peptide Conformation.

ABSTRACT: Halogen bonding is a weak chemical force that has so far mostly found applications in crystal engineering. Despite its potential for use in drug discovery, as a new molecular tool in the direction of molecular recognition events, it has rarely been assessed in biopolymers. Motivated by this fact, we have developed a peptide model system that permits the quantitative evaluation of weak forces in a biologically relevant proteinlike environment and have applied it for the assessment of a halogen bond formed between two amino acid side chains. The influence of a single weak force is measured by detection of the extent to which it modulates the conformation of a cooperatively folding system. We have optimized the amino acid sequence of the model peptide on analogues with a hydrogen bond-forming

SUBMITTER: Danelius E 

PROVIDER: S-EPMC5510091 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature