Clinical and molecular insights into adenoid cystic carcinoma: Neural crest-like stemness as a target.

ABSTRACT:

Objectives

This review surveys trialed therapies and molecular defects in adenoid cystic carcinoma (ACC), with an emphasis on neural crest-like stemness characteristics of newly discovered cancer stem cells (CSCs) and therapies that may target these CSCs.

Data sources

Articles available on Pubmed or OVID MEDLINE databases and unpublished data.

Review methods

Systematic review of articles pertaining to ACC and neural crest-like stem cells.

Results

Adenoid cystic carcinoma of the salivary gland is a slowly growing but relentless cancer that is prone to nerve invasion and metastases. A lack of understanding of molecular etiology and absence of targetable drivers has limited therapy for patients with ACC to surgery and radiation. Currently, no curative treatments a

SUBMITTER: Yarbrough WG 

PROVIDER: S-EPMC5510248 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature