Thyroid states regulate subcellular glucose phosphorylation activity in male mice.

ABSTRACT: The thyroid hormones (THs), triiodothyronine (T₃) and thyroxine (T₄), are very important in organism metabolism and regulate glucose utilization. Hexokinase (HK) is responsible for the first step of glycolysis, catalyzing the conversion of glucose to glucose 6-phosphate. HK has been found in different cellular compartments, and new functions have been attributed to this enzyme. The effects of hyperthyroidism on subcellular glucose phosphorylation in mouse tissues were examined. Tissues were removed, subcellular fractions were isolated from eu- and hyperthyroid (T₃, 0.25 µg/g, i.p. during 21 days) mice and HK activity was assayed. Glucose phosphorylation was increased in the particulate fraction in soleus (312.4% ± 67.1, n = 10), gastrocnemius (369.2%

SUBMITTER: Martins Pecanha FL 

PROVIDER: S-EPMC5510448 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature