Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder.

ABSTRACT:

Importance

Prior studies have demonstrated reduced dendritic spine density in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia. However, it remains unclear how generalizable this finding is in schizophrenia and if it is seen in bipolar disorder, a historically distinct psychiatric condition.

Objective

To assess whether spine loss is present in the DLPFC of individuals with schizophrenia and individuals with bipolar disorder.

Design, setting, and participants

This study used postmortem human brain tissue from individuals with schizophrenia (n=14), individuals with bipolar disorder (n=9), and unaffected control participants (n=19). Tissue samples containing the DLPFC (Brodmann area 46) were Golgi-stained, and basilar dendrites of pyramidal cells in the deep h

SUBMITTER: Konopaske GT 

PROVIDER: S-EPMC5510541 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature