Hypoxia Selectively Enhances Integrin α₅β₁ Receptor Expression in Breast Cancer to Promote Metastasis.

ABSTRACT: Metastasis is the leading cause of breast cancer mortality. Previous studies have implicated hypoxia-induced changes in the composition and stiffness of the extracellular matrix (ECM) in the metastatic process. Therefore, the contribution of potential ECM-binding receptors in this process was explored. Using a bioinformatics approach, the expression of all integrin receptor subunits, in two independent breast cancer patient datasets, were analyzed to determine whether integrin status correlates with a validated hypoxia-inducible gene signature. Subsequently, a large panel of breast cancer cell lines was used to validate that hypoxia induces the expression of integrins that bind to collagen (ITGA1, ITGA11, ITGB1) and fibronectin (ITGA5, ITGB1). Hypoxia-inducible factors (HIF-1 and HIF-2) ar

SUBMITTER: Ju JA 

PROVIDER: S-EPMC5510543 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature