Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Antidepressants are widely used in the treatment of chronic pain. Applied doses are lower than those needed to unfold an antidepressive effect. While efficacy of antidepressants for chronic pain has been reported in large randomized-controlled trials (RCT), there is inconsistent data on adverse effects and tolerability. We aimed at synthesizing data from RCT to explore adverse effect profiles and tolerability of antidepressants for treatment of chronic pain.

Methods

Systematic literature research and meta-analyses were performed regarding side effects and safety of different antidepressants in the treatment of chronic pain according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The National Center for Biotechnology Information l

SUBMITTER: Riediger C 

PROVIDER: S-EPMC5510574 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature