A Three-Dimensional Computational Human Head Model That Captures Live Human Brain Dynamics.

ABSTRACT: Diffuse axonal injury (DAI) is a debilitating consequence of traumatic brain injury (TBI) attributed to abnormal stretching of axons caused by blunt head trauma or acceleration of the head. We developed an anatomically accurate, subject-specific, three-dimensional (3D) computational model of the human brain, and used it to study the dynamic deformations in the substructures of the brain when the head is subjected to rotational accelerations. The computational head models use anatomy and morphology of the white matter fibers obtained using MRI. Subject-specific full-field shearing motions in live human brains obtained through a recently developed tagged MRI imaging technique are then used to validate the models by comparing the measured and predicted heterogeneous dynamic mechanical respons

SUBMITTER: Ganpule S 

PROVIDER: S-EPMC5510681 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature