Catch Bonds at T Cell Interfaces: Impact of Surface Reorganization and Membrane Fluctuations.

ABSTRACT: Catch bonds are characterized by average lifetimes that initially increase with increasing tensile force. Recently, they have been implicated in T cell activation, where small numbers of antigenic receptor-ligand bonds at a cell-cell interface can stimulate a T cell. Here, we use computational methods to investigate small numbers of bonds at the interface between two membranes. We characterize the time-dependent forces on the bonds in response to changes in the membrane shape and the organization of other surface molecules. We then determine the distributions of bond lifetimes using recent force-dependent lifetime data for T cell receptors bound to various ligands. Strong agonists, which exhibit catch bond behavior, are markedly more likely to remain intact than an antagonist whose average

SUBMITTER: Pullen RH 

PROVIDER: S-EPMC5510709 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature