Impact of Zygosity on Bimodal Phenotype Distributions.

ABSTRACT: Allele number, or zygosity, is a clear determinant of gene expression in diploid cells. However, the relationship between the number of copies of a gene and its expression can be hard to anticipate, especially when the gene in question is embedded in a regulatory circuit that contains feedback. Here, we study this question making use of the natural genetic variability of human populations, which allows us to compare the expression profiles of a receptor protein in natural killer cells among donors infected with human cytomegalovirus with one or two copies of the allele. Crucially, the distribution of gene expression in many of the donors is bimodal, which indicates the presence of a positive feedback loop somewhere in the regulatory environment of the gene. Three separate gene-circuit mode

SUBMITTER: Holst-Hansen T 

PROVIDER: S-EPMC5510722 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature