Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG).

ABSTRACT: The Neglected Tropical Disease onchocerciasis is a parasitic disease. Despite many control programmes by the World Health Organization (WHO), large communities in West and Central Africa are still affected. Besides logistic challenges during biannual mass drug administration, the lack of a robust, point-of-care diagnostic is limiting successful eradication of onchocerciasis. Towards the implementation of a non-invasive and point-of-care diagnostic, we have recently reported the discovery of the biomarker N-acetyltyramine-O-glucuronide (NATOG) in human urine samples using a metabolomics-mining approach. NATOG's biomarker value was enhanced during an investigation in a rodent model. Herein, we further detail the specificity of NATOG in active onchocerciasis infections as well as the co-infec

SUBMITTER: Globisch D 

PROVIDER: S-EPMC5510726 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature