Genetic susceptibility to family environment: BDNF Val66met and 5-HTTLPR influence depressive symptoms.

ABSTRACT: Functional genetic polymorphisms associated with Brain-Derived Neurotrophic Factor (BDNF) and serotonin (5-HTTLPR) have demonstrated associations with depression in interaction with environmental stressors. In light of evidence for biological connections between BDNF and serotonin, it is prudent to consider genetic epistasis between variants in these genes in the development of depressive symptoms. The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history. A differential susceptibility model was tested, comparing the effects of family environment on depression scores across different levels of a cumulative plasticity genotyp

SUBMITTER: Dalton ED 

PROVIDER: S-EPMC5510745 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature