Endothelial Glycocalyx-Mediated Nitric Oxide Production in Response to Selective AFM Pulling.

ABSTRACT: Nitric oxide (NO) is a regulatory molecule in the vascular system and its inhibition due to endothelial injury contributes to cardiovascular disease. The glycocalyx is a thin layer of glycolipids, glycoproteins, and proteoglycans on the surface of mammalian epithelial cells. Extracellular forces are transmitted through the glycocalyx to initiate intracellular signaling pathways. In endothelial cells (ECs), previous studies have shown the glycocalyx to be a significant mediator of NO production; degradation of the endothelial glycocalyx layer (EGL) drastically reduces EC production of NO in response to fluid shear stress. However, the specific EGL components involved in this process are not well established. Recent work using short-hairpin RNA approaches in vitro suggest that the proteoglyc

SUBMITTER: Bartosch AMW 

PROVIDER: S-EPMC5510764 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature