Nasopharyngeal microbiota in infants and changes during viral upper respiratory tract infection and acute otitis media.

ABSTRACT:

Background

Interferences between pathogenic bacteria and specific commensals are known. We determined the interactions between nasopharyngeal microbial pathogens and commensals during viral upper respiratory tract infection (URI) and acute otitis media (AOM) in infants.

Methods

We analyzed 971 specimens collected monthly and during URI and AOM episodes from 139 infants. The 16S rRNA V4 gene regions were sequenced on the Illumina MiSeq platform.

Results

Among the high abundant genus-level nasopharyngeal microbiota were Moraxella, Haemophilus, and Streptococcus (3 otopathogen genera), Corynebacterium, Dolosigranulum, Staphylococcus, Acinetobacter, Pseudomonas, and Bifidobacterium. Bacterial diversity was lower in culture-positive samples for Streptococcus pneumoniae, an

SUBMITTER: Chonmaitree T 

PROVIDER: S-EPMC5510840 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature