Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition.

ABSTRACT:

Background

Pregnancy may cause changes in drug disposition. The clinical consequences may be profound and even counterintuitive; in some cases pregnant women may need more than twice their usual drug dose in order to maintain therapeutic drug levels. For antidepressants, evidence on drug disposition in pregnancy is scarce. The aim of this study was to determine the effects of pregnancy on serum levels of selective serotonin reuptake inhibitors (SSRIs) and venlafaxine in a large and naturalistic patient material, in order to provide tentative dose recommendations for pregnant women.

Methods

Using patient data from two routine therapeutic drug monitoring (TDM) services in Norway with linkage to the national birth registry, dose-adjusted serum drug concentrations of SSRIs and v

SUBMITTER: Westin AA 

PROVIDER: S-EPMC5510868 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature