Caucasian Families Exhibit Significant Linkage of Myopia to Chromosome 11p.

ABSTRACT:

Purpose

Myopia is a common visual disorder caused by eye overgrowth, resulting in blurry vision. It affects one in four Americans, and its prevalence is increasing. The genetic mechanisms that underpin myopia are not completely understood. Here, we use genotype data and linkage analyses to identify high-risk genetic loci that are significantly linked to myopia.

Methods

Individuals from 56 Caucasian families with a history of myopia were genotyped on an exome-based array, and the single nucleotide polymorphism (SNP) data were merged with microsatellite genotype data. Refractive error measures on the samples were converted into binary phenotypes consisting of affected, unaffected, or unknown myopia status. Parametric linkage analyses assuming an autosomal dominant model with 9

SUBMITTER: Musolf AM 

PROVIDER: S-EPMC5510992 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature