Ontology highlight
ABSTRACT:
SUBMITTER: Aguilo F
PROVIDER: S-EPMC5511047 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Aguilo Francesca F Zakirova Zuchra Z Nolan Katie K Wagner Ryan R Sharma Rajal R Hogan Megan M Wei Chengguo C Sun Yifei Y Walsh Martin J MJ Kelley Kevin K Zhang Weijia W Ozelius Laurie J LJ Gonzalez-Alegre Pedro P Zwaka Thomas P TP Ehrlich Michelle E ME
Stem cell reports 20170601 1
THAP1 (THAP [Thanatos-associated protein] domain-containing, apoptosis-associated protein 1) is a ubiquitously expressed member of a family of transcription factors with highly conserved DNA-binding and protein-interacting regions. Mutations in THAP1 cause dystonia, DYT6, a neurologic movement disorder. THAP1 downstream targets and the mechanism via which it causes dystonia are largely unknown. Here, we show that wild-type THAP1 regulates embryonic stem cell (ESC) potential, survival, and prolif ...[more]