Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury.

ABSTRACT: Traumatic brain injury-induced acute lung injury (TBI-ALI) is a serious complication after brain injury for which predictive factors are lacking. In this study, we found significantly elevated blood glutamate concentrations in patients with TBI or multiple peripheral trauma (MPT), and patients with more severe injuries showed higher blood glutamate concentrations and longer durations of elevated levels. Although the increase in amplitude was similar between the two groups, the duration was longer in the patients with TBI. There were no significant differences in blood glutamate concentrations in the patients with MPT with regard to ALI status, but the blood glutamate levels were significantly higher in the patients with TBI-ALI than in those without ALI. Moreover, compared to patients with

SUBMITTER: Bai W 

PROVIDER: S-EPMC5511144 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature