Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia.

ABSTRACT: Abnormal functional brain connectivity could be considered an endophenotype of psychosis in schizophrenia. Identifying candidate endophenotypes may serve as a tool for elucidating its biological and neural mechanisms. The present study investigated the similarities and differences of features of brain network connectivity between patients and their first-degree relatives. Independent component analysis was conducted on imaging data collected from 34 healthy controls, 33 schizophrenia patients, and 30 unaffected first-degree relatives. The correlation between functional connectivity with neurocognitive performance and clinical symptoms were calculated. Abnormalities of between-network connectivity largely overlapped in patients and first-degree relatives, but the extent of such abnormalitie

SUBMITTER: Li P 

PROVIDER: S-EPMC5511161 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature