MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF.

ABSTRACT: Esophageal cancer is one of the most lethal cancers worldwide with poor survival and limited therapeutic options. The discovery of microRNAs created a new milestone in cancer research. miR-377 is located in chromosome region 14q32, which is frequently deleted in esophageal squamous cell carcinoma (ESCC), but the biological functions, clinical significance and therapeutic implication of miR-377 in ESCC are largely unknown. In this study, we found that miR-377 expression was significantly downregulated in tumor tissue and serum of patients with ESCC. Both tumor tissue and serum miR-377 expression levels were positively correlated with patient survival. Higher serum miR-377 expression was inversely associated with pathologic tumor stage, distant metastasis, residual tumor status and chemoradi

SUBMITTER: Li B 

PROVIDER: S-EPMC5511242 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature