Family history and risk of breast cancer: an analysis accounting for family structure.

ABSTRACT:

Purpose

Family history is an important risk factor for breast cancer incidence, but the parameters conventionally used to categorize it are based solely on numbers and/or ages of breast cancer cases in the family and take no account of the size and age-structure of the woman's family.

Methods

Using data from the Generations Study, a cohort of over 113,000 women from the general UK population, we analyzed breast cancer risk in relation to first-degree family history using a family history score (FHS) that takes account of the expected number of family cases based on the family's age-structure and national cancer incidence rates.

Results

Breast cancer risk increased significantly (P _trend < 0.0001) with greater FHS. There was a 3.5-fold (95% CI 2.56-4.79) ran

SUBMITTER: Brewer HR 

PROVIDER: S-EPMC5511313 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature