Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters.

ABSTRACT: GABA-ergic interneurons provide diverse inhibitions that are essential for the operation of neuronal circuits in the neocortex. However, the mechanisms that control the functional organization of neocortical interneurons remain largely unknown. Here we show that developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortical interneurons. Spatially clustered neocortical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embryonic medial ganglionic eminence and preoptic area preferentially develop electrical, but not chemical, synapses with each other. This lineage-related electrical coupling forms predominantly between the same interneuron subtype over an extended postnatal period and across a range of distances

SUBMITTER: Zhang XJ 

PROVIDER: S-EPMC5511369 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature