A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway.

ABSTRACT: Single-walled carbon nanotubes are of interest in biomedicine for imaging and molecular sensing applications and as shuttles for various cargos such as chemotherapeutic drugs, peptides, proteins, and oligonucleotides. Carbon nanotube surface chemistry can be modulated for subcellular targeting while preserving photoluminescence for label-free visualization in complex biological environments, making them attractive materials for such studies. The cell nucleus is a potential target for many pathologies including cancer and infectious diseases. Understanding mechanisms of nanomaterial delivery to the nucleus may facilitate diagnostics, drug development, and gene-editing tools. Currently, there are no systematic studies to understand how these nanomaterials gain access to the nucleus. Herein,

SUBMITTER: Budhathoki-Uprety J 

PROVIDER: S-EPMC5511501 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature