Clinically Relevant Concentrations of Anticancer Drugs: A Guide for Nonclinical Studies.

ABSTRACT: Approved and marketed drugs are frequently studied in nonclinical models to evaluate the potential application to additional disease indications or to gain insight about molecular mechanisms of action. A survey of the literature reveals that nonclinical experimental designs (in vitro or in vivo) often include evaluation of drug concentrations or doses that are much higher than what can be achieved in patients (i.e., above the maximally tolerated dose or much higher than the clinically relevant exposures). The results obtained with these high concentrations may be particularly helpful in elucidating off-target effects and toxicities, but it is critical to have a dose-response curve that includes the minimally effective or clinically effective concentration for comparison. We h

SUBMITTER: Liston DR 

PROVIDER: S-EPMC5511563 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature