Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease.

ABSTRACT:

Background

Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention. Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatments is supported by strong clinical evidence.

Objective

This systematic review aims to determine the clinical efficacy and safety of topical corticosteroids for the management of the mucosal alterations of oral cGVHD.

Data sources

Electronic search of different databases was conducted: PubMed, Cochrane library, Grey literature, WHO, and clinical trials.gov for clinical trial registration as well as hand search in the references of relevant articles up to November 2016.

Da

SUBMITTER: Elsaadany BA 

PROVIDER: S-EPMC5511636 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature