Association of Neurocognition With Transition to Psychosis: Baseline Functioning in the Second Phase of the North American Prodrome Longitudinal Study.

ABSTRACT:

Importance

Neurocognition is a central characteristic of schizophrenia and other psychotic disorders. Identifying the pattern and severity of neurocognitive functioning during the "near-psychotic," clinical high-risk (CHR) state of psychosis is necessary to develop accurate risk factors for psychosis and more effective and potentially preventive treatments.

Objectives

To identify core neurocognitive dysfunctions associated with the CHR phase, measure the ability of neurocognitive tests to predict transition to psychosis, and determine if neurocognitive deficits are robust or explained by potential confounders.

Design, setting, and participants

In this case-control study across 8 sites, baseline neurocognitive data were collected from January 2009 to April 2013 in the

SUBMITTER: Seidman LJ 

PROVIDER: S-EPMC5511703 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature