High-Fat Feeding Protects Mice From Ventilator-Induced Lung Injury, Via Neutrophil-Independent Mechanisms.

ABSTRACT:

Objective

Obesity has a complex impact on acute respiratory distress syndrome patients, being associated with increased likelihood of developing the syndrome but reduced likelihood of dying. We propose that such observations are potentially explained by a model in which obesity influences the iatrogenic injury that occurs subsequent to intensive care admission. This study therefore investigated whether fat feeding protected mice from ventilator-induced lung injury.

Design

In vivo study.

Setting

University research laboratory.

Subjects

Wild-type C57Bl/6 mice or tumor necrosis factor receptor 2 knockout mice, either fed a high-fat diet for 12-14 weeks, or age-matched lean controls.

Interventions

Anesthetized mice were ventilated with injurious high tidal v

SUBMITTER: Wilson MR 

PROVIDER: S-EPMC5511730 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature