Mortality among workers exposed to toluene diisocyanate in the US polyurethane foam industry: Update and exposure-response analyses.

ABSTRACT:

Background

Mortality among 4,545 toluene diisocyante (TDI)-exposed workers was updated through 2011. The primary outcome of interest was lung cancer.

Methods

Life table analyses, including internal analyses by exposure duration and cumulative TDI exposure, were conducted.

Results

Compared with the US population, all cause and all cancer mortality was increased. Lung cancer mortality was increased but was not associated with exposure duration or cumulative TDI exposure. In post hoc analyses, lung cancer mortality was associated with employment duration in finishing jobs, but not in finishing jobs involving cutting polyurethane foam.

Conclusions

Dermal exposure, in contrast to inhalational exposure, to TDI is expected to be greater in finishing jobs and may play

SUBMITTER: Pinkerton LE 

PROVIDER: S-EPMC5511732 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature