Allelic frequencies of the hs1.2 enhancer within the immunoglobulin heavy chain region in Dayton, Ohio patients screened for celiac disease with duodenal biopsy.

ABSTRACT:

Background

Genetic and environmental factors contribute to the development of celiac disease (CD), but specific genetic predisposing factors remain poorly understood. One candidate is allele 2 of the hs1.2 enhancer within the immunoglobulin heavy chain region. In humans, there are four possible alleles and a previous study of an Italian cohort demonstrated a significantly increased frequency of allele 2 in patients with CD.

Aims

The purpose of the current study was to determine if a similar association between allele 2 and CD exists in an American population from Dayton, OH.

Methods

Subjects were screened for CD via esophagogastroduodenoscopy with duodenal biopsy. All biopsies were microscopically scored using a modified Marsh-Oberhuber classification. DNA was isolate

SUBMITTER: Liu J 

PROVIDER: S-EPMC5511760 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature