Abnormal CD161⁺ immune cells and retinoic acid receptor-related orphan receptor γt-mediate enhanced IL-17F expression in the setting of genetic hypertension.

ABSTRACT:

Background

Hypertension is considered an immunologic disorder. However, the role of the IL-17 family in genetic hypertension in the spontaneously hypertensive rat (SHR) has not been investigated.

Objective

We tested the hypothesis that enhanced T_H17 programming and IL-17 expression in abundant CD161⁺ immune cells in SHRs represent an abnormal proinflammatory adaptive immune response. Furthermore, we propose that this response is driven by the master regulator retinoic acid receptor-related orphan receptor γt (RORγt) and a nicotinic proinflammatory innate immune response.

Methods

We measured expression of the CD161 surface marker on splenocytes in SHRs and normotensive control Wistar-Kyoto (WKY) rats from birth to adulthood. We compared expression

SUBMITTER: Singh MV 

PROVIDER: S-EPMC5511774 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature