Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla.

ABSTRACT:

Purpose

Hepatic iron content (HIC) quantification via transverse relaxation rate (R2*)-MRI using multi-gradient echo (mGRE) imaging is compromised toward high HIC or at higher fields due to the rapid signal decay. Our study aims at presenting an optimized 2D ultrashort echo time (UTE) sequence for R2* quantification to overcome these limitations.

Methods

Two-dimensional UTE imaging was realized via half-pulse excitation and radial center-out sampling. The sequence includes chemically selective saturation pulses to reduce streaking artifacts from subcutaneous fat, and spatial saturation (sSAT) bands to suppress out-of-slice signals. The sequence employs interleaved multi-echo readout trains to achieve dense temporal sampling of rapid signal decays. Evaluation was done at 1.5

SUBMITTER: Krafft AJ 

PROVIDER: S-EPMC5511783 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature