Parallel Regulation of Memory and Emotion Supports the Suppression of Intrusive Memories.

ABSTRACT: Intrusive memories often take the form of distressing images that emerge into a person's awareness, unbidden. A fundamental goal of clinical neuroscience is to understand the mechanisms allowing people to control these memory intrusions and reduce their emotional impact. Mnemonic control engages a right frontoparietal network that interrupts episodic retrieval by modulating hippocampal activity; less is known, however, about how this mechanism contributes to affect regulation. Here we report evidence in humans (males and females) that stopping episodic retrieval to suppress an unpleasant image triggers parallel inhibition of mnemonic and emotional content. Using fMRI, we found that regulation of both mnemonic and emotional content was driven by a shared frontoparietal inhibitory network an

SUBMITTER: Gagnepain P 

PROVIDER: S-EPMC5511877 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature