Synthesis of a Fluorescently Labeled ⁶⁸Ga-DOTA-TOC Analog for Somatostatin Receptor Targeting.

ABSTRACT: Fluorescently labeled imaging agents can identify surgical margins in real-time to help achieve complete resections and minimize the likelihood of local recurrence. However, photon attenuation limits fluorescence-based imaging to superficial lesions or lesions that are a few millimeters beneath the tissue surface. Contrast agents that are dual-labeled with a radionuclide and fluorescent dye can overcome this limitation and combine quantitative, whole-body nuclear imaging with intraoperative fluorescence imaging. Using a multimodality chelation (MMC) scaffold, IRDye 800CW was conjugated to the clinically used somatostatin analog, ⁶⁸Ga-DOTA-TOC, to produce the dual-labeled analog, ⁶⁸Ga-MMC(IRDye 800CW)-TOC, with high yield and specific activity. In vitro pharmaco

SUBMITTER: Ghosh SC 

PROVIDER: S-EPMC5512127 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature