Uncovering the Repertoire of Endogenous Flaviviral Elements in Aedes Mosquito Genomes.

ABSTRACT: Endogenous viral elements derived from nonretroviral RNA viruses have been described in various animal genomes. Whether they have a biological function, such as host immune protection against related viruses, is a field of intense study. Here, we investigated the repertoire of endogenous flaviviral elements (EFVEs) in Aedes mosquitoes, the vectors of arboviruses such as dengue and chikungunya viruses. Previous studies identified three EFVEs from Aedes albopictus cell lines and one from Aedes aegypti cell lines. However, an in-depth characterization of EFVEs in wild-type mosquito populations and individual mosquitoes in vivo has not been performed. We detected the full-length DNA sequence of the previously described EFVEs and their respective transcripts in sever

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC5512259 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature