Ligand-Enabled Alkynylation of C(sp³ )-H Bonds with Palladium(II) Catalysts.

ABSTRACT: The palladium(II)-catalyzed β- and γ-alkynylation of amide C(sp³ )-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing α-tertiary or α-quaternary carbon centers. The β-methylene C(sp³ )-H bonds of various carbocyclic rings were also successfully alkynylated.

SUBMITTER: Fu H 

PROVIDER: S-EPMC5512278 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature