Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2^+/Q390X mice.

ABSTRACT: It has been established that febrile seizures and its extended syndromes like generalized epilepsy with febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes. In patients, the onset of FS is likely due to the combined effect of temperature and inflammation in genetically vulnerable individuals because fever is often associated with infection. Much effort has been spent to understand the mechanisms underlying fever induction of seizures. In addition to the role of cytokines in FS, previous studies in Scn1a^+/- knockout mice, a model of Dravet syndrome, indicated that temperature elevation alone could result in seizure generation, and the effect of elevated temperature inducing seizures was age-dependent. Her

SUBMITTER: Warner TA 

PROVIDER: S-EPMC5512282 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature