Inhibition of d-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin.

ABSTRACT: The mode of action for desleucyl-oritavancin was investigated by adding an antibiotic to Staphylococcus aureus during its growth in a defined medium containing l,d-[1-¹⁵N]Ala and l-[1-¹³C]Lys, or d-[1-¹⁵N]Ala. ¹³C{¹⁵N} and ¹⁵N{¹³C} rotational-echo double resonance NMR determined that desleucyl-oritavancin inhibited the incorporation of d-[1-¹⁵N]Ala into wall teichoic acid.

SUBMITTER: Chang J 

PROVIDER: S-EPMC5512289 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature