Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8⁺ T Cell Exhaustion Marker Expression.

ABSTRACT: In untreated HIV infection, CD8⁺ T cell exhaustion (i.e., decreased proliferative and effector capacity) is associated with high levels of expression of coinhibitory receptors, including PD-1, T cell immunoreceptor with Ig and ITIM domains (TIGIT), CD160, and 2B4. This is evident for both HIV-specific and non-HIV-specific CD8⁺ T cells. Antiretroviral therapy (ART) initiated during chronic infection decreases but may not completely normalize the expression of such "exhaustion markers." Compared to initiation of ART later in the course of disease, initiation soon after infection reduces some parameters of chronic inflammation and adaptive immune dysfunction. However, it is not known if Early ART (e.g., initiated within the first 6 months after HIV infection) versus Dela

SUBMITTER: Rutishauser RL 

PROVIDER: S-EPMC5512309 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature