Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.

ABSTRACT: The number of people over the age of 60 is expected to double by 2050 according to the WHO. This emphasizes the need to ensure optimized resilience to health stressors in late life. In older adults, influenza is one of the leading causes of catastrophic disability (defined as the loss of independence in daily living and self-care activities). Influenza vaccination is generally perceived to be less protective in older adults, with some studies suggesting that the humoral immune response to the vaccine is further impaired in cytomegalovirus (CMV)-seropositive older people. CMV is a β-herpes virus infection that is generally asymptomatic in healthy individuals. The majority of older adults possess serum antibodies against the virus indicating latent infection. Age-related changes in T-cell-me

SUBMITTER: Merani S 

PROVIDER: S-EPMC5512344 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature