Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis.

ABSTRACT:

Purpose

The purpose of this study was to evaluate progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints of overall survival (OS) in modern clinical trials investigating the efficacy of targeted agents in the second-line treatment of metastatic colorectal cancer (mCRC).

Materials and methods

A systematic search of literature pertaining to randomized phase II and III trials evaluating targeted agents as second-line treatments for mCRC was performed. The strength of the correlation between both PFS and ORR and OS was assessed based on the Pearson's correlation coefficient (R) and the coefficient of determination (R²).

Results

Twenty trials, including a total of 7,571 patients, met the search criteria. The median duration of p

SUBMITTER: Cremolini C 

PROVIDER: S-EPMC5512363 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature