TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice.

ABSTRACT:

Objective

Vertical sleeve gastrectomy (VSG) produces high rates of type 2 diabetes remission; however, the mechanisms responsible remain incompletely defined. VSG increases circulating bile acid concentrations and bile acid signalling through TGR5 improves glucose homeostasis. Therefore, we investigated the role of TGR5 signalling in mediating the glucoregulatory benefits of VSG.

Design

VSG or sham surgery was performed in high-fat-fed male Tgr5^+/+ (wild type) and Tgr5^-/- (knockout) littermates. Sham-operated mice were fed ad libitum or food restricted to match their body weight to VSG-operated mice. Body weight, food intake, energy expenditure, insulin signalling and circulating bile acid profiles were measured and oral glucose tolerance testing, islet

SUBMITTER: McGavigan AK 

PROVIDER: S-EPMC5512436 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature