Aberrant cerebellar connectivity in bipolar disorder with psychosis.

ABSTRACT:

Background

The cerebellum, which modulates affect and cognition in addition to motor functions, may contribute substantially to the pathophysiology of mood and psychotic disorders, such as bipolar disorder. A growing literature points to cerebellar abnormalities in bipolar disorder. However, no studies have investigated the topographic representations of resting state cerebellar networks in bipolar disorder, specifically their functional connectivity to cerebral cortical networks.

Methods

Using a well-defined cerebral cortical parcellation scheme as functional connectivity seeds, we compared ten cerebellar resting state networks in 49 patients with bipolar disorder and a lifetime history of psychotic features and 55 healthy control participants matched for age, sex, and imag

SUBMITTER: Shinn AK 

PROVIDER: S-EPMC5512437 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature