Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation.

ABSTRACT: CK2 is a highly conserved and pleiotropic serine/threonine kinase that promotes many prosurvival and proinflammatory signaling pathways, including PI3K/Akt/mTOR and JAK/STAT. These pathways are essential for CD4⁺ T cell activation and polarization, but little is known about how CK2 functions in T cells. In this article, we demonstrate that CK2 expression and kinase activity are induced upon CD4⁺ T cell activation. Targeting the catalytic activity of CK2 using the next-generation small molecule inhibitor CX-4945 in vitro significantly and specifically inhibited mouse and human Th17 cell differentiation while promoting the generation of Foxp3⁺ regulatory T cells (Tregs). These findings were associated with suppression of PI3K/Akt/mTOR activation and STAT3 pho

SUBMITTER: Gibson SA 

PROVIDER: S-EPMC5512439 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature