Development of molecular tools based on the dopamine D₃ receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior.

ABSTRACT: Dopamine D₃ receptor-mediated networks have been associated with a wide range of neuropsychiatric diseases, drug addiction and food maintained behavior, which makes D₃ a highly promising biological target. The previously described dopamine D₃ receptor ligand FAUC 329 (1) showed protective effects against dopamine depletion in a MPTP mouse model of Parkinson's disease. We used the radioligand [¹⁸F]2, a [¹⁸F]fluoroethoxy substituted analog of the lead compound 1 as a molecular tool for visualization of D₃-rich brain regions including the islands of Calleja. Furthermore, structural modifications are reported leading to the pyrimidylpiperazine derivatives 3 and 9 displaying superior subtype selectivity and preference over seroto

SUBMITTER: Stoßel A 

PROVIDER: S-EPMC5512454 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature