Associations between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes.

ABSTRACT:

Introduction

Existing methods to predict recipient allograft function during deceased-donor kidney procurement are imprecise. Understanding the potential renal reparative role for monocyte chemoattractant protein-1 (MCP-1), a cytokine involved in macrophage recruitment after injury, might help predict allograft outcomes.

Methods

We conducted a sub-study of the multicenter prospective Deceased Donor Study cohort, which evaluated deceased kidney donors from five organ procurement organizations from May 2010 to December 2013. We measured urine MCP-1 (uMCP-1) concentrations from donor samples collected at nephrectomy to determine associations with donor acute kidney injury (AKI), recipient delayed graft function (DGF), 6-month estimated GFR (eGFR), and graft failure. We also ass

SUBMITTER: Mansour SG 

PROVIDER: S-EPMC5512592 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature