Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.

ABSTRACT:

Objectives

Heterogeneity in sepsis-related pathobiology presents a significant challenge. Resolving this heterogeneity presents an opportunity to understand pathobiology and improve patient care. Olfactomedin-4 is a neutrophil subset marker and may contribute to sepsis heterogeneity. Our objective was to evaluate the expression of olfactomedin-4 and characterize neutrophil heterogeneity in children with septic shock.

Design

Single-center, prospective cohort, as well as secondary analysis of existing transcriptomic and proteomic databases.

Setting

Tertiary care PICU.

Patients

Patients from 5 days to 18 years old with septic shock were enrolled. Data collected included the expression of olfactomedin-4 messenger RNA, serum protein concentrations, and percentage of

SUBMITTER: Alder MN 

PROVIDER: S-EPMC5512699 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature