Heterogeneous-Backbone Foldamer Mimics of Zinc Finger Tertiary Structure.

ABSTRACT: A variety of oligomeric backbones with compositions deviating from biomacromolecules can fold in defined ways. Termed "foldamers," these agents have diverse potential applications. A number of protein-inspired secondary structures (e.g., helices, sheets) have been produced from unnatural backbones, yet examples of tertiary folds combining several secondary structural elements in a single entity are rare. One promising strategy to address this challenge is the systematic backbone alteration of natural protein sequences, through which a subset of the native side chains is displayed on an unnatural building block to generate a heterogeneous backbone. A drawback to this approach is that substitution at more than one or two sites often comes at a significant energetic cost to fold stability. He

SUBMITTER: George KL 

PROVIDER: S-EPMC5512705 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature